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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
7.27
Human Site:
S317
Identified Species:
11.43
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
S317
L
D
S
H
L
P
P
S
Q
N
T
S
E
L
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
L295
R
A
L
Q
H
S
Y
L
H
K
D
E
G
N
P
Dog
Lupus familis
XP_852360
326
36788
S317
L
D
S
H
L
P
P
S
Q
N
S
S
E
M
N
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
N317
L
N
S
H
L
P
S
N
Q
S
T
S
E
L
N
Rat
Rattus norvegicus
P35426
303
33780
L295
R
A
L
Q
H
S
Y
L
H
K
E
E
S
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
Q194
D
S
R
I
C
P
G
Q
T
T
A
E
V
N
S
Chicken
Gallus gallus
P13863
303
34670
Y286
K
M
A
L
N
H
P
Y
F
D
D
L
D
K
S
Frog
Xenopus laevis
Q91727
319
35666
F295
D
A
L
L
H
P
F
F
A
D
D
P
Q
A
C
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
K293
Y
A
Q
P
F
P
S
K
K
P
S
L
E
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
E308
P
S
A
L
A
C
L
E
H
D
Y
F
Q
Q
E
Honey Bee
Apis mellifera
XP_391955
457
50351
H449
T
A
A
Q
A
L
R
H
R
Y
F
A
E
D
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
D317
D
D
D
T
E
V
E
D
D
D
D
E
E
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y286
R
Q
A
L
E
H
E
Y
F
K
D
L
E
V
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y286
R
A
A
L
E
H
E
Y
F
K
D
L
G
G
M
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
A290
R
I
S
A
R
R
A
A
I
H
P
Y
F
Q
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
0
86.6
N.A.
73.3
0
N.A.
6.6
6.6
6.6
13.3
N.A.
0
6.6
N.A.
13.3
P-Site Similarity:
100
N.A.
0
100
N.A.
93.3
0
N.A.
13.3
33.3
20
26.6
N.A.
20
33.3
N.A.
20
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
34
7
14
0
7
7
7
0
7
7
0
7
0
% A
% Cys:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
7
% C
% Asp:
20
20
7
0
0
0
0
7
7
27
40
0
7
20
7
% D
% Glu:
0
0
0
0
20
0
20
7
0
0
7
27
47
7
20
% E
% Phe:
0
0
0
0
7
0
7
7
20
0
7
7
7
0
0
% F
% Gly:
0
0
0
0
0
0
7
0
0
0
0
0
14
7
0
% G
% His:
0
0
0
20
20
20
0
7
20
7
0
0
0
0
0
% H
% Ile:
0
7
0
7
0
0
0
0
7
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
7
7
27
0
0
0
7
0
% K
% Leu:
20
0
20
34
20
7
7
14
0
0
0
27
0
14
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
7
% M
% Asn:
0
7
0
0
7
0
0
7
0
14
0
0
0
14
20
% N
% Pro:
7
0
0
7
0
40
20
0
0
7
7
7
0
0
14
% P
% Gln:
0
7
7
20
0
0
0
7
20
0
0
0
14
14
0
% Q
% Arg:
34
0
7
0
7
7
7
0
7
0
0
0
0
0
7
% R
% Ser:
0
14
27
0
0
14
14
14
0
7
14
20
7
0
14
% S
% Thr:
7
0
0
7
0
0
0
0
7
7
14
0
0
0
0
% T
% Val:
0
0
0
0
0
7
0
0
0
0
0
0
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
14
20
0
7
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _